Chondrocyte biology
WebChondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells (MSCs) … WebSep 10, 2024 · Chondrocytes are the cells responsible for cartilage formation, and they are crucial for the process of endochondral ossification, which is useful for bone development. Also, by mimicking skeletal development chondrocytes play a critical role in fracture repair. What is Chondroblast and osteoblast?
Chondrocyte biology
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WebTo investigate chondrocyte biology in an organized structure, limb explant cultures have been established that allow the cultivation of the entire cartilaginous skeletal elements. In these organ cultures, the arrangement of chondrocytes in the cartilage elements and their interaction with the surrou … Cartilage explant cultures WebNov 15, 2024 · The first detailed nanometer-scale study of the three-dimensional anatomy of a chondrocyte primary cilium was carried out in 1978 [] by exhaustive serial TEM imaging of ultrathin sections.Since then, electron tomography, or imaging biological structures using transmission electron microscopy (TEM) for 3D reconstruction, is widely used [3,19]. ...
WebGeneral description The chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. WebSep 9, 2024 · Chondrocytes, or chondrocytes in lacunae, are cells found in cartilage connective tissue. The number of chondrocytes found in cartilage determines how 'bendy' the cartilage is. When looking...
WebNov 9, 2024 · Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively predict treatment outcomes, while in silico modeling can help unravel that complexity. WebJan 22, 2001 · Chondrocytes of articular cartilage produce and retain significant amounts of active and inactive BMPs, known to increase extracellular matrix synthesis and induce chondrogenesis and osteogenesis. For example, both normal and OA chondrocytes synthesize and retain BMP-7 (also called OP-1 [osteogenic protein 1]) [ 7 ].
WebApr 14, 2024 · Cell Genomics ( @CellGenomics ), is a new Gold open access journal from Cell Press publishing multidisciplinary research at the forefront of genetics and genomics. The journal aims to bring ...
WebHuman Chondrocytes, HC, are derived from normal human articular cartilage where they produce and maintain the extracellular matrix of cartilage, including type II collagen. Chondrocytes grown in monolayer culture on a solid surface tend to lose their phenotypic markers and became de-differentiated to a fibroblast-like phenotype. tickle a stingrayWebEmbryonic development of articular cartilage has not been well understood and the role of doublecortin (DCX) in determination of chondrocyte phenotype is unknown. Here, we use a DCX promoter-driven eGFP reporter mouse model to study the dynamic gene expression profiles in mouse embryonic handplates at E12.5 to E13.5 when the condensed … tickle attack scoreWebMar 3, 2024 · Chondrocytes were exposed to mechanical stress with intensity of 2,000 μstrain at a frequency of 1 Hz for 4 h. For the control group, cells were cultured in the same condition without mechanical stress stimulation for 4 h. RNA Isolation and Real-Time Polymerase Chain Reaction (RT-PCR) the long queen motherhoodWebHC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. tickle attack on momWebInterleukin-1beta, a cytokine that is present in the synovial fluid of rheumatoid arthritis patients, induces many metabolic changes on the chondrocyte biology. Compared with … tickle attayoWebSep 10, 2024 · Chondrocytes are the cells responsible for cartilage formation, and they are crucial for the process of endochondral ossification, which is useful for bone … the long quest for computational thinkingWebChondrocyte culture is an efficient target system for evaluation of the pharmacological and toxicological effects of drugs acting on cartilaginous tissue. Many types of culture exist and have their own advantages and drawbacks. For example, in monolayer culture … tickle at back of throat causing cough