WebOct 18, 2024 · TFEB promotes transcription and expression of its target genes by ... Substantial time-dependent decreases in lysosomal enzyme activity [e.g., cathepsin B, D, and L (CTSB, CTSD, and CTSL)], LMP ... WebJan 13, 2024 · Although the downregulation of Tfeb in the heart significantly decreased the number of autophagic vacuoles and inhibited autosis during I/R, the activation of Tfeb activity via 3,4-dimethoxychalcone, an activator of Tfeb, aggravated myocardial injury during I/R. ... Gabarap and Vps11, and lysosomal function, including Ctsb, Ctsd, Hexb, Cln3 …
TFEB Promotes Prostate Cancer Progression - Frontiers
WebScale bar: 10 μm. (D) Quantitative RT-PCR analyses of ciliobrevin A- and dynasore-treated cells showed increased transcription of TFEB target genes (LC3, SQSTM1, MCOLN1, CTSB, CTSF, and TFEB) after inhibition of endocytosis with dynasore or inhibition of retrograde trafficking with ciliobrevin A. Bar graphs represent fold change in mRNA levels ... WebConsistent with the increased expression of TFEB mRNA, we found a substantial increase in the protein expression level of TFEB in uninfected Ctsb −/− BMDMs relative to those … bitlockerとは 使い方
Activation of TFEB-mediated autophagy by trehalose attenuates ...
WebAcronym Definition; CFTB: Computers for the Blind (Richardson, TX): CFTB: Change for the Better: CFTB: California Franchise Tax Board: CFTB: Connect for the Best (employment … WebTo conclude, we identified that four DEARGs (CTSB, ITGB1, CXCR4, TNFSF10) may be critical in atherosclerosis development and provide potential predictive markers and therapeutic targets for determining a treatment strategy for advanced carotid atherosclerosis.Identification of DEARGs in Advanced Carotid Atherosclerosis. We … WebIn primary LECs, HG treatment resulted in decreased transcription factor EB (TFEB) and cathepsin B (CTSB) activity, and increased lysosomal size and pH values. Moreover, TFEB-mediated dysfunctional lysosomes resulted from excessive oxidative stress in LECs under HG conditions. Furthermore, TFEB activation by curcumin analog C1 alleviated HG ... bitlocker在哪里找