Durocher cip2a
WebAug 12, 2009 · Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that inhibits c-Myc protein degradation in cancer cells. CIP2A has been found to be overexpressed in different human cancers, but its clinical relevance has not yet been established. WebJun 16, 2011 · Cancerous inhibitor of PP2A (CIP2A) is a recently described inhibitor of PP2A in breast and gastric cancer. The aim of this study was to investigate whether CIP2A played a role in CML and whether PP2A or its inhibitor proteins CIP2A or SET could predict clinical outcome.
Durocher cip2a
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WebFeb 8, 2024 · CIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. In BRCA-deficient cells, the... WebFeb 8, 2024 · CIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. In …
WebAug 22, 2024 · Conclusion: High expression of CIP2A was a poor indicator of the prognosis of EGJA, and CIP2A may be a new biomarker for the diagnosis and treatment of EGJA. The meta-analysis suggested that CIP2A expression can be a predictive marker of overall survival, disease-specific survival, and time to tumor progression in patients with solid … WebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its elevation …
WebCIP2A inactivates protein phosphatase 2A (PP2A) which down-regulates Akt (Protein Kinase B) phosphorylation and stabilizes c-Myc (c-Myc oncogene product) in cancer … WebDurocher D, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nature Cancer. 2: 1357-1371. PMID 35121901 DOI: ... Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding …
WebMay 26, 2024 · CIP2A is overexpressed in MM and is associated with poor prognosis. (a) Cell viability was determined by CCK-8 assay after Dex treatment in MM.1S and MM.1R cells for 24 h.(b) Cell viability was ...
WebFeb 8, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it forms a complex with MDC1 and... green cat perth mapWebNature Cancer The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer – Nature Cancer - Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from … flow is nullWebFeb 7, 2024 · that CIP2A binds to PP2A B56a and B56c tumor suppressor subunits directly. Both the CIP2A N-terminal region and CIP2A dimerization contribute to maximal B56 binding. We further show that B56 bind-ing determines CIP2A protein stability in human cell lines. Together, these results provide important insights into poorly understood flow isotype controlWebThe CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Durocher and colleagues identify CIP2A through synthetic … flowis settings 2022WebHere, we identify CIP2A as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei... flow isolation valveWebformation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Thus, our data show that CIP2A is a human oncopro-tein that inhibits PP2A and … flow is now power automategreen cat poop with blood