Improving protein succinylation sites
WebFeb 23, 2024 · K. slooffiae decreased intestinal epithelial lysine succinylation levels, and these proteins were especially enriched in the glycolysis pathway. We demonstrated that K. slooffiae promoted intestinal epithelial glycolysis by decreasing lysine succinylation by activating sirtuin 5 (SIRT5). WebImproving Protein Succinylation Sites Prediction Using Features Extracted from Protein Language Model - LMSuccSite/README.md at main · KCLabMTU/LMSuccSite Skip to contentToggle navigation Sign up Product Actions Automate any workflow Packages Host and manage packages Security Find and fix vulnerabilities
Improving protein succinylation sites
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WebOct 1, 2024 · As mitochondria are thought to be lysine succinylation hot spots, the proteins primarily affected by succinylation can naturally be expected to be the mitochondrial ones. However, with few exceptions ( 24, 43 ), most studies on eukaryotic succinylomes were performed on whole-cell extracts.
WebEnter the email address you signed up with and we'll email you a reset link. WebDec 27, 2024 · Locating succinylation sites using experimental methods, such as mass spectrometry is very laborious. Hence, computational methods are favored using machine …
WebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, … WebApr 7, 2016 · A new predictor named pSuc-FFSEA, which can predict succinylation sites in protein sequences by feature fusion and stacking ensemble algorithm is developed, which showed excellent robustness and performed better than the previous prediction tools. 2 PDF
WebOct 8, 2024 · A novel approach that combines features from supervised word embedding with embedding from a protein language model called ProtT5-XL-UniRef50 in a deep learning framework to predict protein succinylation sites is presented. Protein succinylation is an important post-translational modification (PTM) responsible for many vital …
WebOct 8, 2024 · Europe PMC is an archive of life sciences journal literature. high road burgh castleWebJun 27, 2013 · After removing overlapping sites, we identified a total of 2,565 Lys succinylation sites from 779 proteins in mouse cells ( Figures 1 B and 1C). We found that some proteins were highly succinylated, including CPS1 with 47 sites and hydroxyacyl-coenzyme A dehydrogenase (HADHA) with 32 sites ( Figure 1 C and Tables S1 A–S1B). high road byfleetWebFeb 12, 2024 · The original collection comprised 2,521 succinylation and 24,128 non-succinylation sites from 896 unique proteins. To avoid overestimations due to homology … how many carbon atoms does heptyne haveWebNov 11, 2024 · Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of … high road brownie stuffed cookie doughWebApr 5, 2016 · Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 is an efficient desuccinylase. Although many mammalian proteins have recently been found to be regulated by lysine succinylation and SIRT5, the physiological significance of succinylation and SIRT5 remains unknown. how many carbon atoms have sn 4 in geraniolWebMar 22, 2024 · Purified KGDHC can succinylate and modify the activity of multiple proteins including albumin and other enzymes of the TCA cycle including the pyruvate dehydrogenase complex (PDHC) and ICDH. The greater effectiveness of KGDHC than succinyl CoA suggests that the catalysis owing to the E2k succinyltransferase is … how many carbon atoms does methane haveWebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine … how many carbon atoms in a buckyball